Active motion of particles in aqueous solution may lead to interesting collective phenomena such as pattern formation or macroscopic fluid flows. I will discuss two examples where this can be observed. First, I will present lattice Boltzmann simulations of a microscopic model for cytoplasmic streaming in algal cells. Here, myosin motors entrain the surrounding fluid by walking along actin filaments while dragging vesicles or other organelles. I will pay particular attention to how the high speeds observed in experiments can be achieved by assuming a layer of lower viscosity at the outer wall of the simulated compartment. The second example is a system of sedimenting self-propelled particles with the additional property of bottom-heaviness, which results in a tendency of particles to swim upwards. I will give analytical results for the dilute limit and numerical results for the interacting case where particles form vortices and columns.