Lässig
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Statistical Physics and Quantitative Biology
University of Cologne
 
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Physics of Biological Systems
Winter Semester 08/09
Ralf Bundschuh and Michael Laessig
  1. Introduction
  2. Fundamentals of polymer statistics
    1. Random walks and Brownian motion
    2. Gaussian polymers
    3. Self-avoiding polymers
    4. Wormlike chains
  3. DNA
    1. DNA structure
    2. Physical properties of DNA
    3. DNA melting
    4. Sequence properties of DNA
  4. RNA
    1. Physical properties of RNA
    2. Secondary and tertiary structure
    3. Functional design of RNA structures
  5. Proteins
    1. Protein structure
    2. Functions of proteins
    3. Protein folding
  6. Protein-DNA interactions
    1. Sequence specificity
    2. Function: Transcriptional networks
    3. Simple transcriptional networks
    4. Stochasticity in transcriptional networks
  7. Molecular Information
    1. Sequence similarity
    2. Local motifs
    3. Gene expression
  8. Genome evolution
    1. Fitness and selection
    2. Error threshold and quasispecies
    3. Neutral evolution, population fluctuations
    4. Towards a comprehensive picture
  9. Evolution of phenotypes and function
    1. Evolutionary game theory and applications
    2. Evolution of regulatory interactions
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