Quantitative Evolutionary Biology

Michael Lässig, Kay Hofmann, Thomas Wiehe

Tutoring

Dr. Simone Pompei, pompei@thp.uni-koeln.de

References:

11.4. Fundamentals of statistical genetics I: selection and mutations
- [Gillespie]
18.4. Fundamentals of statistical genetics II: genetic drift and recombination
- [Gillespie]
25.4. Proteins I: Structure
- [Krebbs] Chapter I, II
02.5. Proteins II: Evolution
- [Krebbs] Chapter I, II
16.5. Conservation and adaptation in protein evolution
- "The interface of protein structure, protein biophysics, and molecular evolution." Protein Sci. 2012 Jun;21(6):769-85. doi: 10.1002/pro.2071. Epub 2012 Apr 23.
06.6. Inference of selection I: Single-nucleotide polymorphisms
- [Gillespie] Chapter II,
-"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism." Tajima F., Genetics. 1989 Nov;123(3):585-95.
13.6. Coalescent theory of neutral and adaptive processes
- "Evolution in a flat fitness landscape". B. Derrida and L. Peliti, Bull. Math. Biol. 53, 355-382 (1991)
- "Genealogies of rapidly adapting populations". Richard A. Neher and Oskar Hallatschek Proc Natl Acad Sci U S A. 2013 Jan 8;110(2)
20.6. Inference of selection II: Haplotype-based methods
- [Walsh2]
27.6. Function and evolution of a core protein: p53
- [LI] Chapter X
04.7. Macro-evolution of proteins
11.7. De-novo gene evolution
18.7. Host-pathogen co-evolution
"Epochal Evolution Shapes the Phylodynamics of Interpandemic Influenza A (H3N2) in Humans". Katia Koelle et al. Science. Vol. 314 no. 5807
"Biological and biomedical implications of the coevolution of pathogens and their hosts". Woolhouse, MEJ et al. Nature Genetics 32 (4)
"Unifying the Epidemiological and Evolutionary Dynamics of Pathogens" Grenfell, B. T. et al, Science 303 (5656)

Books:

[Gillespie]: "Population Genetics: A concise guide". John H. Gillespie.
[Walsh1]: "Genetics and Analysis of Quantitative Traits". Michael Lynch and Bruce Walsh.
[Walsh2]: "Evolution and Selection of Quantitative Traits". Michael Lynch and Bruce Walsh.
[Krebbs]: "Lewin's Genes X". Jocelyn E. Krebbs, Elliott S. Goldstein, Stephen T. Kilpatrick
[Li]: "Molecular Evolution". Wen-Hsiung Li