Statistical Physics and Quantitative Biology
University of Cologne
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Equilibrium Statistical Mechanics and Field Theory

Sequence alignment is the most widely used data analysis tool in molecular biology. Detecting and quantifying sequence similarities is an intricate statistical problem, which has profound connections to the statistical physics of systems with quenched disorder. Other projects in this area are concerned with long-range correlations in genomes and with the statistics of RNA secondary structures.

The secondary structure of a random RNA molecule is frozen at low temperatures (a) and molten at higher temperatures (b).
Selected physics publications
Delocalization transitions of semiflexible manifolds
R. Bundschuh and M. Lässig, Phys. Rev. E65, 61502, (2002)
Vicinal surfaces and the Calogero-Sutherland model
M. Lässig, Phys. Rev. Lett. 77, 526, (1996)
Geometry of the renormalization group, with an application in two dimensions
M. Lässig, Nucl. Phys. B334, 652, (1990)
Selected applications to biology and bioinformatics
Freezing of random RNA
M. Lässig and K. Wiese, Phys. Rev. Lett. 96, 228101, (2006)
Correlated Random Networks
J. Berg and M. Lässig, Phys. Rev. Lett. 89, 228701, (2002)

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