Lässig

research

group

Statistical Physics and Quantitative Biology

University of Cologne

Refereed Publications

Population immunity predicts evolutionary trajectories of SARS-CoV-2

Meijers M., Ruchnewitz D., Eberhardt J., Łuksza M., Lässig M., Cell 186, 5151–5164 (2023)

Steering and controlling evolution — from bioengineering to fighting pathogens

Lässig M., Mustonen V., Nourmohammad A., Nat Rev Genet, (2023)

Towards evolutionary predictions: Current promises and challenges

Wortel M., Agashe D., Bailey S., Bank C., Bisschop K., Blankers T., Cairns J.,
Colizzi E., Cusseddu D.,
Desai M., van Dijk B., Egas M., Ellers J., Groot A., Heckel D., Johnson M., Kraaijeveld K., Krug J., Laan L.,
Lässig M., Lind P., Meijer J., Noble L., Okasha S., Rainey P., Rozen D., Shitut S., Tans S., Tenaillon O.,
Teotónio H., de Visser J.,
Visser M., Vroomans R., Werner G., Wertheim B., Pennings P., Evolutionary Applications, 3-21, 16(1), (2023)

Two modes of evolution shape bacterial strain diversity in the mammalian gut for
thousands of generations

Frazão N., Konrad A., Amicone M., Seixas E., Güleresi D., Lässig M. and Gordo I.,
Nature Communications, 13 (5604) , (2022)

Stochasticity of infectious outbreaks and consequences for optimal interventions

Morán-Tovar R., Gruell H., Klein F., Lässig M., J. Phys. A: Math. Theor. 55
384008 (2022)

Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in
children

Dewald F., Suárez I., Johnen R., Grossbach J., Moran-Tovar R., Steger G.,
Joachim
A., Rubio G.H., Fries M. , Behr F., Kley J., Lingnau A., Kretschmer A., Gude C., Baeza-Flores G., Laveaga
del
Valle D., Roblero-Hernandez A., Magana-Cerino J., Hernandez A.T., Ruiz-Quinones J., Schega K., Linne V.,
Junker L., Wunsch M., Heger E., Knops E., Di Cristanziano V., Meyer M., Hünseler C., Weber L.T., Lüers L.C.,
Quade G., Wisplinghoff H., Tiemann C., Zotz R., Jomaa H., Pranada A., Herzum I., Cullen P., Schmitz F.J.,
Philipsen P., Kirchner G., Knabbe C., Hellmich M., Buess M., Wolff A., Kossow A., Niessen J., Jeworutzki S.,
Schräpler J.-P., Lässig M., Dötsch J., Fätkenheuer D., Kaiser R., Beyer A., Rybniker J., Klein F., Nature
Communications, 13 (3640) , (2022)

Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite
neutralizers

Vanshylla K., Fan C., Wunsch M., Poopalasingam N., Meijers M., Kreer C.,
Kleipass F., Ruchnewitz D., Ercanoglu M., Gruell H., Münn F. Pohl K., Janicki H., Nolden T., Bartl S., Stein
S., Augustin M., Dewald F., Gieselmann L., Schommers P., Schulz T., Sander L., Koch M., Łuksza M., Lässig
M., Bjorkman P., Klein F., Cell Host & Microbe, 69-82.e10, 30(1), (2022)

Clinical and Genomic Characterization of SARS CoV-2 infections in mRNA
Vaccinated Health Care Personnel in New York City

Robilotti E.V., Whiting K., Lucca A., Poon C., Guest R., McMillen T., Jani K.,
Solovyov A., Kelson S., Browne K., Freeswick S., Hohl T.M., Korenstein D., Ruchnewitz D., Lässig M., Łuksza
M., Greenbaum B., Seshan V.E., Babady N.E., Kamboj M., Clinical Infectious Diseases, ciab886, (2022)

Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing
antibody

Meijers M., Vanshylla K., Gruell H., Klein F., Lässig M., PNAS 118 (30)
e2104651118, (2021)

Antigenic waves of virus–immune coevolution

Marchi J., Lässig M., Walczak A.M., Mora T., PNAS 118 (27) e2103398118, (2021)

Metabolic fitness landscapes predict the evolution of antibiotic resistance

Pinheiro F., Warsi O., Andersson D.I., Lässig M., Nature Ecol. Evol, in press
(2021)

Adaptive evolution of hybrid bacteria by horizontal gene transfer

Power J.J., Pinheiro F., Pompei S., Kovacova V., Yüksel M., Rathmann I.,
Förster
M., Lässig M., Maier B., PNAS 11, 118 (10), (2021)

Eco-evolutionary control of pathogens

Lässig M., Mustonen V., PNAS 117:19694-19704 (2020)

Horizontal gene transfer overrides mutation in Escherichia coli colonizing the
mammalian gut

Frazão N., Sousa A., Lässig M., and Gordo I., PNAS:201906958 (2019)

Survival of the simplest in microbial evolution

Held T., Klemmer D., Lässig M., Nature Communications 10: 2472 (2019)

Fitness cost of reassortment in human influenza

Mara Villa, Michael Lässig, PLOS Pathogens 13(11): e1006685 (2017)

Predictive Modeling of Influenza Shows the Promise of Applied Evolutionary
Biology

Dylan H. Morris, Katelyn M. Gostic, Simone Pompei, Trevor Bedford, Marta
Łuksza,
Richard A. Neher, Bryan T. Grenfell, Michael Lässig, John W. McCauley, Trends in Microbiology, Volume 0 ,
Issue 0 (2017)

Adaptive Evolution of Gene Expression in Drosophila

Armita Nourmohammad, Joachim Rambeau, Torsten Held, Viera Kovacova, Johannes
Berg, Michael Lässig, Cell Reports 20, 1385-1395 (2017)

Predicting evolution

Michael Lässig, Ville Mustonen, Aleksandra M. Walczak, Nature Ecol. Evol. 1,
077
(9 pages) (2017)

Multiple-line inference of selection on quantitative traits

N. Riedel, B. S. Khatri, M. Lässig, J. Berg, Genetics 201, 305-322 (2015)

Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a
hemimetabolous insect

L. Sachs, Y.-T. Chen, A. Drechsler, J. A. Lynch, K. A. Panfilio, M. Lässig, J.
Berg, S. Roth, eLife 4:e05502 (2015)

Rate and cost of adaptation in the Drosophila genome

S. Schiffels, M. Lässig* and V. Mustonen*, arXiv:1409.1946 (2014)

(*) equal contributions

(*) equal contributions

Can we read the future from a tree?

M. Lässig and M. Łuksza, insight article, eLife, 3:e05060 (2014)

Adaptive evolution of molecular phenotypes

T. Held, A. Nourmohammad, and M. Lässig, J. Stat. Mech., P09029 (39 pages)
(2014)

A predictive fitness model for influenza

M. Łuksza and M. Lässig, Nature, 507, 57-61 (2014)

Universality and predictability in molecular quantitative genetics

A. Nourmohammad*, T. Held*, and M. Lässig, Current Opinion in Genetics and
Development 23, 684-93 (2013)

(*) equal contributions

(*) equal contributions

Fitness landscape of nucleosome positioning

D. Weghorn and M. Lässig, Proc. Natl. Acad. Sci. 110, 10988–93 (2013)

Evolution of molecular phenotypes under stabilizing selection

A. Nourmohammad, S. Schiffels, and M. Lässig, J. Stat. Mech. P01012 (34 pages),
(2013)

GraphAlignment: Bayesian pairwise alignment of biological networks

M. Kolar, J. Meier, V. Mustonen, M. Lässig, and J. Berg, BMC Systems Biology 6,
144, (2012)

Clonal interference in the evolution of influenza

N. Strelkowa and M. Lässig, Genetics 192, 671 - 682 (2012)

Chance and risk in adaptive evolution

M.Lässig, Proc. Natl. Acad. Sci. 109, 4719-20, (2012)

Formation of regulatory modules by local sequence duplication

A. Nourmohammad and M. Lässig, PLoS Comp. Biol., PLoS Comput Biol 7, e1002167
(12
pages), (2011)

Emergent Neutrality in Adaptive Asexual Evolution

Stephan Schiffels, Gergely Szöllösi, Ville Mustonen, and Michael Lässig,
Genetics
189, 1361 - 75, (2011)

Nonlinear fitness landscape of a molecular pathway

Lilia Perfeito, Stéphane Ghozzi, Johannes Berg, Karin Schnetz, Michael Lässig,
PloS Genetics 7, e1002160 (10 pages), (2011)

Fitness flux and ubiquity of adaptive evolution

V. Mustonen and M. Lässig, Proc. Natl. Acad. Sci. 107, 4248-53, (2010)

Significance analysis and statistical mechanics: an application to clustering

M. Luksza, M. Lässig, and J. Berg, Phys. Rev. Lett. 105, 220601 (4 pages),
(2010)

From fitness landscapes to seascapes: non-equilibrium dynamics of selection
and
adaptation

V. Mustonen and M. Lässig, Trends Genet 25, 111-9, (2009)

Energy-dependent fitness: a quantitative model for the evolution of yeast
transcription factor binding sites

V. Mustonen, J. Kinney, CG. Callan Jr, and M. Lässig, Proc. Natl. Acad. Sci.
105,
12376-81, (2008)

From protein interactions to functional annotation: graph alignment in Herpes

M. Kolar, Lässig, and J. Berg, BMC Syst Biol. 2, 90, (2008)

Molecular evolution under fitness fluctuations

V. Mustonen and M. Lässig, Phys Rev Lett. 100, 108101, (2008)

Adaptations to fluctuating selection in

*Drosophila*V. Mustonen and M. Lässig, Proc. Natl. Acad. Sci. 104, 2277-82, (2007)

From biophysics to evolutionary genetics: statistical aspects of gene
regulation

M. Lässig, BMC Bioinformatics 8 Suppl 6, S7, (2007)

Cross-species analysis of biological networks by Bayesian alignment

J. Berg and M. Lässig, Proc. Natl. Acad. Sci. 103, 10967, (2006)

Freezing of random RNA

M. Lässig and K. Wiese, Phys. Rev. Lett. 96, 228101, (2006)

A minimal stochastic model for influenza evolution

F. Tria, M. Lässig, L. Peliti, S. Franz, J. Stat. Mech. P07008 (2005)

Biodiversity and productivity in model ecosystems I: Coexistence conditions
for
competing species

U. Bastolla, M. Lässig, S. Manrubia, and A. Valleriani, J. Theor. Biol. 235,
521,
(2005)

Biodiversity and productivity in model ecosystems II: Species assembly and
food
web structure

U. Bastolla, M. Lässig, S. Manrubia, and A. Valleriani, J. Theor. Biol. 235,
531,
(2005)

Evolutionary population genetics of promoters: predicting binding sites and
functional phylogenies

V. Mustonen and M. Lässig, Proc. Natl. Acad. Sci. 103, 10967, (2005)

Solvable sequence evolution models and genomic correlations

P.W. Messer, P.F. Arndt, and M. Lässig, Phys. Rev. Lett. 94, 138103, (2005)

Toward an accurate statistics of gapped alignments

M. Kschischo, M. Lässig, and Y.-K. Yu, Bull. Math. Biol. 67, 169, (2005)

Universality of log-range correlations in expansion-randomization systems

P.W. Messer, M. Lässig, and P.F. Arndt, J. Stat. Mech., P10004, (2005)

Adaptive evolution of transcription factor binding sites

J. Berg, S. Willmann, and M. Lässig, BMC Evol. Biol. 4, 42, (2004)

Local graph alignment and motif search in biological networks

J. Berg and M. Lässig, Proc. Natl. Acad. Sci. 101, 14689, (2004)

Of statistics and genomes

D. Tautz and M. Lässig, Trends in Genetics 20, 344, (2004)

Structure and evolution of protein networks: a statistical model for link
dynamics and gene duplications

J. Berg, M. Lässig, and A. Wagner, BMC Evol. Biol. 4, 51, (2004)

Evolutionary games and quasispecies

F. Tria, M. Lässig, L. Peliti, Europhys. Lett. 62, 446 (2003)

Stochastic evolution of transcription factor binding sites

J. Berg and M. Lässig, Biophysics (Moscow) 48, Suppl. 1 (2003)

Correlated Random Networks

J. Berg and M. Lässig, Phys. Rev. Lett. 89, 228701, (2002)

Delocalization transitions of semiflexible manifolds

R. Bundschuh and M. Lässig, Phys. Rev. E65, 61502, (2002)

Dynamics and topology of species networks

U. Bastolla, M. Lässig, S. Manrubia, and A. Valleriani, in

*Biological Evolution and Statistical Physics*, ed. M. Lässig and A. Valleriani, Springer Verlag (2002) (refereed)Spatio-Temporal Modes of Speciation

M. Rost and M. Lässig, in

*Biological Evolution and Statistical Physics*, ed. M. Lässig and A.Valleriani, Springer Verlag (2002), (refereed)Diversity patterns from ecological models at dynamical equilibrium

U. Bastolla, M. Lässig, S. Manrubia, and A. Valleriani, J. Theor. Biol. 212,
11,
(2001)

Shape of ecological networks

M. Lässig, U. Bastolla, S. Manrubia, and A. Valleriani, Phys. Rev. Lett. 86,
4418, (2001)

Dynamical anomalies and intermittency in Burgers turbulence

M. Lässig, Phys. Rev. Lett. 84, 2618, (2000)

Finite-temperature sequence alignment

M. Kschischo and M. Lässig, Pacific Symposium on Biocomputing 5, (2000)
(refereed)

Scaling laws and similarity detection in sequence alignment with gaps

D. Drasdo, T. Hwa, and M. Lässig, J. Comput. Biol. 7, 115, (2000)

Semiflexible polymers with attractive interactions

R. Bundschuh, M. Lässig, and R. Lipowsky, Eur. Phys. J. B 3, 295, (2000)

Optimizing Smith-Waterman alignments

R. Olsen, T. Hwa, and M. Lässig, Pacific Symposium on Biocomputing 4, 302
(1999)
(refereed)

A statistical theory of sequence alignment with gaps

D. Drasdo, T. Hwa, and M. Lässig, Proceedings of the sixth international
conference on intelligent systems for molecular biology (ISMB 98), AAAI Press, Menlo Park (1998) (refereed)

On growth, disorder, and field theory (review article)

M. Lässig, J. Phys. C 10, 9905 (1998)

Optimal detection of sequence similarity by local alignment

T. Hwa and M. Lässig, Proceedings of the second annual conference on
computational molecular biology (RECOMB 98), ACM Press, New York (1998) (refereed)

Quantized scaling of growing surfaces

M. Lässig, Phys Rev. Lett. 80, 2366 (1998)

Reply on a Comment to Upper critical dimension of the Kardar-Parisi-Zhang
equation

H. Kinzelbach and M. Lässig, Phys. Rev. Lett. 80, 889 (1998)

DNA sequence alignment and critical phenomena

D. Drasdo, T. Hwa, and M. Lässig, in Statistical Mechanics in Physics and
Biology, ed. D. Wirtz et al., Boston (1997) (refereed)

Upper critical dimension of the Kardar-Parisi-Zhang equation

M. Lässig and H. Kinzelbach, Phys. Rev. Lett. 78, 903, (1997)

Comment on "Simplest possible self-organized critical system"

R. Bundschuh and M. Lässig, Phys. Rev. Lett. 77, 4273, (1996)

Directed polymers in high dimensions

R. Bundschuh and M. Lässig, Phys. Rev. E 54, 304, (1996)

Similarity detection and localization

T. Hwa and M. Lässig, Phys. Rev. Lett. 76, 2591, (1996)

Vicinal surfaces and the Calogero-Sutherland model

M. Lässig, Phys. Rev. Lett. 77, 526, (1996)

Depinning in a random medium

H. Kinzelbach and M. Lässig, J. Phys. A 28, 6535, (1995)

Interacting flux lines in a random medium

H. Kinzelbach and M. Lässig, Phys. Rev. Lett. 75, 2208, (1995)

On the renormalization of the Kardar-Parisi-Zhang equation

M. Lässig, Nucl. Phys. B448, 559, (1995)

Strongly inhomogeneous surface growth and directed polymers

H. Kallabis and M. Lässig, Phys. Rev. Lett. 75, 1578, (1995)

Bundles of interacting strings in two dimensions

C. Hiergeist, M. Lässig, and R. Lipowsky, Europhys. Lett. 28, 103, (1994)

Critical roughening of interfaces: A new class of renormalizable field
theories

M. Lässig and R. Lipowsky, Phys. Rev. Lett. 70, 1131, (1993)

Multiple crossover phenomena and scale hopping in two dimensions

M. Lässig, Nucl. Phys. B 380, 601, (1992)

Exact universal amplitude ratios in two-dimensional systems near criticality

M. Lässig, Phys. Rev. Lett. 67, 3737, (1991)

Finite-size effects in theories with factorizable S-matrices

M. Lässig and M.J. Martins, Nucl. Phys. B354, 666, (1991)

Hilbert space and structure constants of descendant fields in two-dimensional
conformal theories

M. Lässig and G. Mussardo, Comput. Phys. Comm. 66, 71, (1991)

New hierarchies of multicriticality in two-dimensional field theory

M. Lässig, Phys. Lett. B 278, 439, (1991)

The scaling region of the tricritical Ising model in two dimensions

M. Lässig, G. Mussardo and J.L. Cardy, Nucl. Phys. B348, 591 (1991)

Geometry of the renormalization group, with an application in two dimensions

M. Lässig, Nucl. Phys. B334, 652, (1990)

Book, book contributions, and other publications

Epidemiological and evolutionary analysis of the 2014 Ebola virus outbreak

M. Łuksza, T.Bedford, and M. Lässig, arxiv:1411.1722 (2014)

Bayesian analysis of biological networks: Clusters, motifs, cross-species
correlations

J. Berg and M. Lässig,

*in*Statistical and evolutionary analysis of biological networks, ed. M.P.H. Stumpf and C. Wiuf, Imperial College Press, London (2009)From biophysics to evolutionary genetics: Statistical aspects of gene
regulation

*in*Structural approaches to sequence evolution: Molecules, networks, populations, U. Bastolla et al. eds., Springer Verlag (2006)

Den Text des Lebens verstehen - Herausforderungen postgenomischer Forschung an
Biologie und Physik in Deutschland (Understanding the text of life - challenges to post-genomic research in
Germany)

M. Lässig, E. Sackmann, D. Tautz, and M. Vingron, PhysikJournal 3 Nr. 10, 24,
(2004)

Biological Evolution and Statistical Physics

ed. M. Lässig and A. Valleriani, Springer Verlag (2002)

Universal aspects of interacting lines and surfaces

M. Lässig and R.Lipowsky,

*in*Fundamental Problems in Statistical Mechanics VIII, ed.H.van Beijeren and M.H. Ernst, Elsevier, Amsterdam (1994)